Elkins and Tygarts Valley will both hit the road for conference contests tonight, while Buckhannon-Upshur plays host to Webster County for an intra-conference clash.
Class AAA, No. 4 Elkins will look to remain unbeaten on the season when it faces Fairmont Senior for a Big 10 Conference matchup at East-West Stadium.
The Tigers (4-0), which rolled to a 63-21 victory over Preston last Friday, defeated Fairmont Senior at home last season, 21-20.
Running backs L.J. Lawrence, who had 214 yards last week, Clayton Collett and Nick Martin will look to spearhead Elkins' Single Wingle offensive attack.
Collett, a first-team All-State selection last season, has 381 yards rushing and eight touchdowns this year.
Martin has 344 yards on the ground this season for the Tigers.
The Polar Bears, ranked 12th in Class AA, will look to running backs Noah Harmon and Ryder Skarzinski to lead the attack.
"Fairmont Senior lost their quarterback in Week 2, so they've changed from what they normally try to do," Elkins coach Greg Hott said. "They're looking to run more than pass."
Fairmont Senior (2-1) is coming of a bye week. The Polar Bears defeating Preston 19-6 in their last contest on Sept. 7.
Tygarts Valley, meanwhile, will be searching for its first win of the season at No. 6 East Hardy.
The Bulldogs (0-3) were idle last week and dropped a 47-18 decision to South Harrison in their last contest.
Tygarts Valley is led by running back Andrew Torres and quarterback Brandon Pritt.
The Cougars (3-0) defeated Pocahontas County 39-0 last Friday. East Hardy will look to quarterback Shawn Skovron and receiver Josh Parker to lead its offense.
After dropping its first three contests of the season, Buckhannon-Upshur will look make it two straight in front of a homecoming crowd tonight.
The Bucs (1-3) defeated North Marion 40-20 last week for their first win of the season.
B-U is led by quarterback Patrick Crim, who threw for 160 yards and three touchdowns last week.
Running backs Cole Payne and Seth Cutright are also key elements in the Bucs' offense.
Webster County (1-3) is coming off a 15-8 loss to Roane County last week.
Running backs David Muzny and Joe Collins, and senior quarterback Luther Stoots are the Highlanders' top threats offensively.
Lewis County, Pocahontas County and Pendleton County will also be in action this evening.
Lewis County will travel to Herbert Hoover for a non-conference matchup.
The Minutemen (2-2) are coming off a 34-13 victory over East Fairmont last week.
Running backs Caleb Butcher and Mark Metzgar will look to power Lewis County.
Butcher had 155 yards rushing last week, while Metzgar added 111 yards on the ground.
The Huskies (0-4) are coming a 46-7 loss to Tolisa last Friday.
Like Tygarts Valley, Pocahontas County will be searching for its first win off the season when they visit Richwood tonight for a non-conference contest.
The Warriors (0-4) are coming off a 39-0 loss to East Hardy at home last week.
Running back Kyler Doss and quarterback Andrew Morrison will look to get Pocahontas County's offense going agasint Richwood (2-2), which lost to Midland Trial 15-13 last Friday.
Pendleton County will also be on the road when it faces a tough teast at Class A, No. 3 Meadow Bridge.
The Wildcats (3-1) are coming off a 21-0 win over Fishburne (Va.) last week. Meadow Bridge (4-0) defeated Fayetteville 8-6 in its last contest.
All contests are scheduled for 7:30 p.m. kickoffs.