Both West Virginia and Syracuse will be short-handed for Saturday's New Era Pinstripe Bowl at Yankee Stadium.
Mountaineer senior Joe Madsen has been ruled academically ineligible and did not make the trip to New York City.
Madsen, a 6-foot-4, 305-pound center, started a school-record 50 times during his career with the Mountaineers.
He was the lone WVU player not to make the bowl trip.
Madsen also missed the 2010 Champs Sports Bowl due to academic issues.
"It's disappointing that he didn't take care of business," West Virginia coach Dana Holgorsen said. "The expectation for our guys is to go to class, to get good grades and leave West Virginia with a good quality education and a degree. Joey fell short of that, and we're disappointed that he did."
The Orange, meanwhile, will be without sophomore tailback Adonis Ameen-Moore and reserve tight end Max Beaulieu for Saturday's game.
Syracuse head coach Doug Marrone didn't give a reason for the two suspensions.
Ameen-Moore rushed for 108 yards on 30 carries and scored six touchdowns in the six games he played. Beaulieu played in just one game this season.
Starting outside linebacker Marquis Spruill also has been disciplined. He will not play "a significant portion" of Saturday's contest.
Meanwhile, players coaches and university staff participating in the New Era Pinstripe Bowl will visit the New York Stock Exchange this morning.
WVU head coach Dana Holgorsen and Syracuse senior quarterback Ryan Nassib will ring the Opening Bell.
The Mountaineers were forced to practice indoors on Wednesday due to inclement weather in the New York area.
Select players and coaches from each team met with the media on Wednesday night in preparation for the game, which is set for 3 p.m. on Saturday and televised on ESPN